{
  "name": "gdc-cancer-genomics-mcp",
  "title": "HealthMesh · NCI GDC Cancer Genomics MCP",
  "version": "0.1.1",
  "description": "Live NCI Genomic Data Commons (GDC) open-access data: list cancer genomics projects (TCGA, TARGET, CPTAC, MMRF, HCMI ...) with case counts; search cases by project, primary site, somatically mutated gene, sex, vital status, AJCC stage, diagnosis and age; full clinical record for a case (demographic, diagnoses, treatments, follow-up, file summary, optional somatic mutations); and the most frequently mutated genes in a project (or one gene's frequency and hotspot mutations) as affected / SSM-tested cases. No key; open-access tier only.",
  "healthmesh_domain": "Research, Trials & Genomics",
  "datasets": [
    "RES-06"
  ],
  "mcp_endpoint": "https://gdc-cancer-genomics.healthmesh.ai/mcp",
  "transport": "Streamable HTTP (stateless, JSON responses)",
  "authorization": "none",
  "auth_mode": "off",
  "docs": "https://github.com/HendrikK/healthmesh/tree/main/servers/gdc-cancer-genomics-mcp#readme",
  "contact": "hendrik.kleine@gmail.com",
  "data_source": {
    "name": "NCI Genomic Data Commons (GDC) API, open-access tier",
    "url": "https://api.gdc.cancer.gov/",
    "license": "GDC open-access data (NIH/NCI), free, no key; cite GDC and source projects; controlled-access data not served",
    "refresh": "live (12 h edge cache; GDC data releases every few months)"
  },
  "tools": [
    {
      "name": "gdc_list_projects",
      "title": "List GDC cancer genomics projects",
      "description": "Lists NCI Genomic Data Commons projects (TCGA, TARGET, CPTAC, MMRF, HCMI, BEATAML, CGCI, ...) with program, primary sites, disease types and case/file counts. Filter by program, primary site (substring, e.g. 'lung'), disease type or name text. Use the project_id with gdc_search_cases and gdc_count_mutations."
    },
    {
      "name": "gdc_search_cases",
      "title": "Search GDC cases",
      "description": "Searches open-access GDC cases by project, primary site, somatically mutated gene (cases with >=1 simple somatic mutation in the gene, as on the GDC portal), sex at birth, vital status, AJCC stage (pathologic or clinical; 'Stage IV' includes IVA/IVB/IVC), primary diagnosis text and age at diagnosis. Returns total and case rows (case UUID, TCGA-style submitter_id, demographics, stage, diagnosis)."
    },
    {
      "name": "gdc_get_case",
      "title": "Get a GDC case",
      "description": "Full open-access clinical record for one GDC case by case UUID or submitter_id (e.g. TCGA-A1-A0SB): project, demographic (sex, race, vital status, days to death), diagnoses (age, primary diagnosis, ICD-10, morphology, AJCC stage/TNM, grade), treatments (type, agents, intent, outcome), follow-ups summary, and file counts by data category and experimental strategy. Optional somatic mutations (SSMs) with gene and protein change."
    },
    {
      "name": "gdc_count_mutations",
      "title": "Mutated genes in a GDC project",
      "description": "Most frequently mutated genes in a GDC project, ranked by the number of cases with >=1 somatic simple mutation (SSM), with the percentage of SSM-tested cases (the GDC portal's 'mutation frequency'). With gene=, returns that gene's affected cases and percentage plus its most recurrent protein changes (e.g. KRAS G12D in TCGA-PAAD)."
    },
    {
      "name": "gdc_describe_dataset",
      "title": "Describe the NCI GDC source",
      "description": "Explains the NCI Genomic Data Commons source: current data release (live), programs, open- vs controlled-access tiers, what a case / SSM-tested case means, how mutation frequencies are counted, and caveats."
    }
  ]
}